412 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

    Gemma LM Fisher et al.
    Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

    Juan Carlos Rengifo-Gonzalez et al.
    The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek et al.
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Cell Biology

    A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

    Sho W Suzuki et al.
    PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

    Gaspare La Rocca et al.
    A new genetically engineered mouse strain is described in which miRNA activity can be acutely and reversibly inhibited, showing that in a subset of adult tissues miRNA activity is dispensable under homeostatic conditions but becomes essential during tissue regeneration.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

    Mohd Anisul et al.
    Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
    1. Biochemistry and Chemical Biology

    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

    Urszula Nowicka et al.
    Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A prion accelerates proliferation at the expense of lifespan

    David M Garcia et al.
    In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.

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