237 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart

    Amy Heidersbach, Chris Saxby ... Deepak Srivastava
    microRNA-1 plays an essential role in the development and functioning of the heart by ensuring that genes for striated, rather than smooth, muscle are expressed there.
    1. Neuroscience

    Inferring eye position from populations of lateral intraparietal neurons

    Arnulf BA Graf, Richard A Andersen
    An area of visual-motor cortex called the lateral intraparietal area encodes eye position signals that support visually-guided behaviors and image stabilization.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Core promoter factor TAF9B regulates neuronal gene expression

    Francisco J Herrera, Teppei Yamaguchi ... Robert Tjian
    An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
    1. Neuroscience

    Resting state functional connectivity in the human spinal cord

    Robert L Barry, Seth A Smith ... John C Gore
    Resting state spinal fMRI will be useful in studies of normal spinal cord function and central nervous system disorders.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera, Bibhusita Pani ... Evgeny Nudler
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Neuroscience

    Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

    Félix Leroy, Boris Lamotte d'Incamps ... Daniel Zytnicki
    Contrary to a long-standing hypothesis, the neuronal death that leads to muscle wastage in amyotrophic lateral sclerosis does not result from overactivity of those neurons during development.
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni, Angelica Aguilera-Gomez ... Catherine Rabouille
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.
    1. Cell Biology
    2. Neuroscience

    The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

    Carmela Sidrauski, Anna M McGeachy ... Peter Walter
    Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

    Carmela Sidrauski, Jordan C Tsai ... Peter Walter
    A drug-like molecule called ISRIB, which activates the translation initiation factor eIF2B, antagonizes stress responses as diverse as protein misfolding and nutrient deprivation, and restores protein synthesis, enhancing memory.
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang, Mingliang Qu ... Dongxian Zhang
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.

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