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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

    Daniel Chen, Polyxeni Philippidou ... Helen C. Miranda
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

    Maria I Lazaro-Pena, Adam B Cornwell ... Andrew V Samuelson
    The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet, Jenna L Tancredi ... Erin K O'Shea
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Immunology and Inflammation

    The meningeal transcriptional response to traumatic brain injury and aging

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Transcriptional analyses provide an atlas of how traumatic brain injury and aging shape meningeal cell composition and gene expression.
    1. Cell Biology

    Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

    King Faisal Yambire, Christine Rostosky ... Nuno Raimundo
    Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

    Nodar Makharashvili, Sucheta Arora ... Tanya T Paull
    The CtIP DNA repair enzyme is required for the removal of transcription-associated lesions in eukaryotic cells.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control

    Mykola Roiuk, Marilena Neff, Aurelio A Teleman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

    Marcel Proske, Robert Janowski ... Dierk Niessing
    Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

    Raphael Trenker, Devan Diwanji ... Natalia Jura
    Cryo-EM structures uncover glycosylation in the ectodomains of full-length HER4 homodimer and HER2/HER4 heterodimer complexes, revealing how the binding of various growth factors alters dynamics at the dimerization interface.
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