17,693 results found
    1. Medicine
    2. Neuroscience

    Science Forum: Consensus-based guidance for conducting and reporting multi-analyst studies

    Balazs Aczel, Barnabas Szaszi ... Eric-Jan Wagenmakers
    Using multiple analysts to independently analyze the same dataset has the potential to explore and strengthen the robustness of results and conclusions in basic and applied research.
    1. Computational and Systems Biology
    2. Developmental Biology

    A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

    Hernán Morales-Navarrete, Fabián Segovia-Miranda ... Yannis Kalaidzidis
    MotionTracking is freely available software that can generate multi-scale geometrical models of mammalian tissue and perform quantitative analysis of tissue architecture.
    1. Neuroscience

    Spatiotemporally precise optogenetic activation of sensory neurons in freely walking Drosophila

    Brian D DeAngelis, Jacob A Zavatone-Veth ... Damon A Clark
    A simple, computationally efficient method provides spatiotemporally precise optogenetic perturbations in freely walking Drosophila, revealing the asymmetries and region-specificity of behavioral programs evoked by activating mechanosensory and chemosensory neurons.
    1. Neuroscience

    CaImAn an open source tool for scalable calcium imaging data analysis

    Andrea Giovannucci, Johannes Friedrich ... Eftychios A Pnevmatikakis
    CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
    1. Neuroscience

    NeuroQuery, comprehensive meta-analysis of human brain mapping

    Jérôme Dockès, Russell A Poldrack ... Gaël Varoquaux
    Full-text analysis of the human brain-imaging literature can predict the spatial distribution of observations in the brain given the description of a subject of study.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Robust and annotation-free analysis of alternative splicing across diverse cell types in mice

    Gonzalo Benegas, Jonathan Fischer, Yun S Song
    A robust computational pipeline for alternative splicing analysis is developed and applied to large-scale cell atlases, overcoming technical challenges and making results available for the scientific community to explore via public interactive browsers.
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth, Matthias Griebel ... Robert Blum
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
    1. Ecology

    Meta-analysis challenges a textbook example of status signalling and demonstrates publication bias

    Alfredo Sánchez-Tójar, Shinichi Nakagawa ... Julia Schroeder
    Meta-analysis takes down a textbook example in behavioural and evolutionary ecology, and demonstrates the existence of biases in the current scientific publishing culture.
    1. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe, Hermann-Georg Holzhütter ... Michele Mishto
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Robust model-based analysis of single-particle tracking experiments with Spot-On

    Anders S Hansen, Maxime Woringer ... Xavier Darzacq
    Spot-On is an easy-to-use website that makes a rigorous and bias-corrected modeling framework for analysis of single-molecule tracking experiments available to all.

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