5,075 results found
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Microbiology and Infectious Disease

    Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

    Edward JD Greenwood et al.
    A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.
    1. Human Biology and Medicine

    Meta-Research: Why we need to report more than 'Data were Analyzed by t-tests or ANOVA'

    Tracey L Weissgerber et al.
    Many papers in basic biomedical science do not contain the information that is needed to determine what statistical tests were used and to verify the results of these tests.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

    Rachel W Anantha et al.
    Systematic analyses of natural variants and artificial mutants establish functional landscapes of BRCA1 for homology-directed repair (HDR) and therapy resistance and identify the BRCA1-PALB2 interaction as a key control point for HDR pathway choice.
    1. Cell Biology

    Ubiquitylation-independent activation of Notch signalling by Delta

    Nicole Berndt et al.
    Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

    Anna Zhou et al.
    Structural analysis of the ATP synthase – in combination with evolutionary covariance analysis – reveals the fold of the a subunit and shows that the enzyme can adopt several different conformations, which support the Brownian ratchet model for generating rotation.
    1. Neuroscience

    Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons

    Martial A Dufour et al.
    The development of the electrical phenotype of neurons can be precisely quantified and dissected using a combination of multi-variate statistical analyses and a systematic electrophysiological characterization of electrical properties.

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