Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes that are critical for normal developmental processes.

Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.

An inferred mechanistic model that connects sequence (genotype) to function (constitutive gene expression phenotype) for any random sequence in Escherichia coli reveals the structure of constitutive promoters and how they evolve.

Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.

Single-cell transcriptomic analysis of developing retinal ganglion cells in mice suggests that their diversification into 45 discrete types occurs via the gradual restriction of multipotential precursors.

Repeated evolution of eye regression in subterranean mammals helps identify genes and regulatory elements involved in visual perception and development of the eye, and predicts candidate sequences with a potential role in ocular disorders.

Relatively few genes have evolved vertically from the last universal common ancestor to modern prokaryotes, and phylogenetic analysis of these genes demonstrates a great genetic distance between Archaea and Bacteria.

Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.

Biochemical studies in combination with computational modeling and molecular dynamics simulations reveal that the lipid bilayer promotes intramembrane proteolysis by stabilizing the enzyme-substrate complex and the protease active site.

Pervasive ‘futile cycling’ by chromatin-modifying factors suggests a mechanism for creating new links in gene regulatory networks.