1,241 results found
    1. Evolutionary Biology

    Contingency and chance erase necessity in the experimental evolution of ancestral proteins

    Victoria Cochran Xie et al.
    Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular sequences on long phylogenetic timescales.
    1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi et al.
    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.
    1. Chromosomes and Gene Expression

    Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

    Joshua M Galanter et al.
    An epigenome-wide study shows that ethnic self-identification and genetically determined ancestry both make important independent contributions to DNA methylation levels.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

    Conor J Howard et al.
    Reconstructing ancestral enzymes has revealed that a switch in kinase substrate preference evolved via an expanded specificity intermediate that is tolerated in vivo, thus providing a path for kinase diversification.
    1. Evolutionary Biology
    2. Plant Biology

    Independent evolution of ancestral and novel defenses in a genus of toxic plants (Erysimum, Brassicaceae)

    Tobias Züst et al.
    A gain-of-function in a new chemical defense resulted in no trade-offs and and independent evolution between novel and ancestral defenses, suggesting low redundancy among different defensive chemicals.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

    Luisa CS Antunes et al.
    Phylogenomics provides support for the Gram-positive type of bacterial cell envelope being a derived character that arose independently multiple times through loss of an ancestral outer membrane.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde

    Iman Hamid et al.
    Admixture-mediated adaptation to malaria in a human population demonstrates that detectible signatures in genomic patterns of ancestry can be leveraged to better characterize recent selection in populations with mixed ancestry.
    1. Evolutionary Biology

    The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

    Daniel B Mills et al.
    Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

    Taylor B Updegrove et al.
    Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.

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