623 results found
    1. Genetics and Genomics
    2. Plant Biology

    Contesting the presence of wheat in the British Isles 8,000 years ago by assessing ancient DNA authenticity from low-coverage data

    Clemens L Weiß et al.
    A computational method to authenticate low-coverage ancient DNA experiments shows that putative wheat sequences from 8000 years old sediments are most likely not of ancient origin.
    1. Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson et al.
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

    Devanshi Jain et al.
    The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
  1. From ancient DNA to decay: an interview with Jessica Metcalf

    Jessica Metcalf of the University of Colorado is rapidly becoming an expert regarding the science of death. "I've been into dead things for a while," she told eLife. "They hold a lot of information."
    1. Cell Biology

    Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response

    Esti Singer et al.
    The dual function of an ancient prokaryotic enzyme, which is linked to specific metabolite signals, may have been the evolutionary driving force behind its dual localization in eukaryotes.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

    Kirsten I Bos et al.
    The analysis of 18th century Y. pestis genomes reveals a bacterial lineage that might be responsible for the 400-year period of European plague epidemics from the Renaissance through early modern times.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A vocabulary of ancient peptides at the origin of folded proteins

    Vikram Alva et al.
    A comparative study of modern proteins identifies 40 fragments that may represent the observable remnants of a primordial RNA-peptide world.
    1. Genetics and Genomics

    A new genus of horse from Pleistocene North America

    Peter D Heintzman et al.
    The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.
    1. Genetics and Genomics

    Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution

    Matthias Meyer et al.
    DNA sequences from the Middle Pleistocene reveal that the extinct Eurasian straight-tusked elephants were closely related to today's African forest elephants (Loxodonta cyclotis) in Africa.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

    Ben Krause-Kyora et al.
    Ancient hepatitis B virus (HBV) genomes were reconstructed from up to 7000-year-old Stone Age human skeletons, suggesting a long-time complex co-evolution with human populations.

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