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    1. Cell Biology
    2. Genetics and Genomics

    Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    Breanna Lam, Kathrin M Kajderowicz ... Sinisa Hrvatin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Evolutionary Biology

    Coenzyme-Protein Interactions since Early Life

    Alma Carolina Sanchez-Rocha, Mikhail Makarov ... Klára Hlouchová
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    MeiQing Han, Xia Wang ... Fan Yang
    Gut microbiota dysbiosis increased Nos2 expression through the 'gut–lung axis', and altered intracellular antimicrobial and anti-inflammatory environment by abnormal NO, ROS, and Defb1, thereby promoting Mycobacteria colonization in mouse lungs.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

    Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev
    The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
    1. Neuroscience

    Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Mechanism of barotaxis in marine zooplankton

    Luis Alberto Bezares Calderón, Réza Shahidi, Gáspár Jékely
    Ciliated zooplankton larvae sense pressure by ciliary photoreceptor cells, which increase the beating of locomotor cilia via a serotonergic motor circuit leading to rapid upward swimming during barotaxis.
    1. Evolutionary Biology

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element

    Zachary H Williams, Alvaro Dafonte Imedio ... Welkin E Johnson
    The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.
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