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    1. Microbiology and Infectious Disease

    The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification

    Russell P Swift, Rubayet Elahi ... Sean T Prigge
    Plasmodium falciparum apicoplast SufS is required for both iron-sulfur synthesis and tRNA modification by MnmA, a novel paradigm that is likely to apply to other plastid-containing organisms.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Discovery of a metabolic alternative to the classical mevalonate pathway

    Nikki Dellas, Suzanne T Thomas ... Joseph P Noel
    A combination of phylogenetic and biochemical analyses suggest that some unexpected variations in the synthesis of isoprenoids may be widespread across all three domains of life.
    1. Cell Biology
    2. Genetics and Genomics

    Resurrecting essential amino acid biosynthesis in mammalian cells

    Julie Trolle, Ross M McBee ... Harris H Wang
    Mammalian cells were engineered to synthesize valine, a metabolic capacity that had been lost from the lineage of higher eukaryotes for >500 million years.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant, Angel F Cisneros ... Christian R Landry
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants

    Panagiotis Sapountzis, Mariya Zhukova ... Jacobus J Boomsma
    Domestication of endosymbiotic Mollicutes may have resolved nitrogen-recycling challenges for attine ants and enabled the evolutionary derived leaf-cutting ants to fully exploit their herbivorous niches.
    1. Genetics and Genomics

    Single-amino acid variants reveal evolutionary processes that shape the biogeography of a global SAR11 subclade

    Tom O Delmont, Evan Kiefl ... A Murat Eren
    An in-depth metagenomic analysis of possibly the most abundant and widespread microbial lineage in the surface ocean teases apart evolutionary processes that maintain its genomic heterogeneity and biogeography.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

    Long-Feng Lu, Can Zhang ... Shun Li
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Separating phases of allopolyploid evolution with resynthesized and natural Capsella bursa-pastoris

    Tianlin Duan, Adrien Sicard ... Martin Lascoux
    A comparison between artificially created allopolyploids and natural ones reveals that the latter underwent significant evolutionary steps after their formation.
    1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Evolutionary Biology

    Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis

    Courtney W Stairs, Laura Eme ... Andrew J Roger
    A number of microbial eukaryotes have adapted to low oxygen conditions by acquiring a gene that allows their mitochondrial electron transport chain to continue to function when oxygen is scarce.