466 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

    Xiaodi Yu et al.
    Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.
    1. Structural Biology and Molecular Biophysics

    Molecular mechanism of TRPV2 channel modulation by cannabidiol

    Ruth A Pumroy et al.
    Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.
    1. Chromosomes and Gene Expression

    Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

    Jennifer Munkley et al.
    The male steroid hormone testosterone regulates splicing patterns by controlling the expression of a key splicing regulator protein.
    1. Cell Biology
    2. Evolutionary Biology

    The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates

    Shin Matsubara et al.
    Oocyte maturation and ovulation in the sister group of vertebrates, Ciona intestinalis Type A, are triggered by Ci-VP, the Ciona homolog of a typical neruopeptide, vasopressin.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Protein engineering expands the effector recognition profile of a rice NLR immune receptor

    Juan Carlos De la Concepcion et al.
    Structure-led protein engineering can expand the effector recognition profile of plant intracellular NLR immune receptors, providing a proof-of-principle for the development of novel disease resistance mechanisms in plants.
    1. Neuroscience

    Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

    Xiangling Meng et al.
    A combination of mouse genetics and biochemistry approaches reveals neurexophilin4 (Nxph4) as a context-specific α-neurexin ligand, which regulates Golgi-granule cell inhibitory synapses and motor functions.
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin et al.
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Extensive ribosome and RF2 rearrangements during translation termination

    Egor Svidritskiy et al.
    Ensemble cryo-EM visualizes how structural rearrangements poise the newly made protein and release factor RF2 to dissociate in preparation for ribosome recycling.

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