889 results found
  1. Meta-research

    Meta-Research: A Collection of Articles

    Edited by Peter A Rodgers
    The study of science itself is a growing field of research.
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    COVID-19: A Collection of Articles

    Edited by Diane M Harper et al.
    eLife has published the following articles on SARS-CoV-2 and COVID-19.
    1. Ecology
    2. Microbiology and Infectious Disease

    Transparent soil microcosms for live-cell imaging and non-destructive stable isotope probing of soil microorganisms

    Kriti Sharma et al.
    Two optically transparent substrates enable the exploration of the ecophysiology and spatiotemporal organization and activities of bacteria and fungi within heterogeneous soil-like environments.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Microbiology and Infectious Disease

    Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite

    Stephanie G Hays, Kimberley D Seed
    Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.
    1. Structural Biology and Molecular Biophysics

    Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

    Yihe Huang et al.
    High-resolution structures of human TRPM2 in different functional states provided the mechanism underlying ligand recognition, channel activation and inhibition.
    1. Structural Biology and Molecular Biophysics

    Structure of the human lipid-gated cation channel TRPC3

    Chen Fan et al.
    Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.
    1. Neuroscience

    Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells

    Marina Garrett et al.
    VIP inhibitory neurons are active in response to novel images but are suppressed by familiar stimuli and show ramping activity when expected stimuli are omitted.
    1. Neuroscience

    Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses

    Dario Maschi, Vitaly A Klyachko
    Release site heterogeneity represents a previously unknown level of structural and functional organization within individual active zones in central synapses, which determines the spatiotemporal dynamics of multi-vesicular release.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

    Ching-Ju Tsai et al.
    The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.

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