995 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants

    Laura Cornelissen et al.
    Alpha EEG oscillations emerge at 4 months of age during sevoflurane general anesthesia, and unlike in adults, have a widespread spatial distribution that likely reflects differences in brain development.
    1. Neuroscience

    A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans

    Laura D Lewis et al.
    Intracranial recordings of human brain activity during awakening from general anesthesia exhibit a brief brain state not seen during loss of consciousness, in which stimuli elicit large electrophysiological responses that resemble those seen in sleep.
    1. Neuroscience
    2. Physics of Living Systems

    Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia

    Andrew R McKinstry-Wu et al.
    Responses to anesthetics differ among individuals and fluctuate stochastically despite constant drug concentration, however, the amount of noise driving transitions between the responsive and the unresponsive state is conserved.
    1. Medicine
    2. Neuroscience

    Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist

    Jesus Javier Ballesteros et al.
    Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
    1. Neuroscience

    An electrophysiological marker of arousal level in humans

    Janna D Lendner et al.
    Non-oscillatory brain activity can be used to monitor arousal levels during both NREM and REM sleep as well as under general anesthesia with propofol.
    1. Neuroscience
    2. Medicine

    Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury

    Shawniqua T Williams et al.
    The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
    1. Neuroscience

    Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness

    Oluwaseun Akeju et al.
    Patterns of communication between the thalamus and the cortex are correlated with anesthesia-induced loss of consciousness and recovery.
    1. Neuroscience

    Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

    Kevin A Bolding et al.
    Intracortical circuits in mouse olfactory cortex stabilize odor-evoked activity patterns when upstream inputs, from olfactory bulb, become degraded under anesthesia.
    1. Neuroscience
    2. Medicine

    Neuroscience: Awakened by a sleeping pill

    Oluwaseun Akeju, Emery N Brown
    Insight
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  1. Point of View: Four erroneous beliefs thwarting more trustworthy research

    Mark Yarborough et al.
    Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.

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