1,161 results found
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

    Katherine T Best et al.
    Adult Scleraxis-lineage cells are not required for successful tendon healing but are required for maintenance of tendon homeostasis.
    1. Neuroscience

    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

    Jeong-Kyu Han et al.
    Cerebellar STAT3 is indispensable for proper expression of fear memory network processing.
    1. Cancer Biology
    2. Neuroscience

    Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

    Zhi Zhang et al.
    Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
    1. Genetics and Genomics
    2. Medicine

    Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

    Chiara Fallerini et al.
    In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.
    1. Neuroscience

    Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

    Anna J Bowen et al.
    Parabrachial neurons expressing CGRP relay affective components of ascending pain information via distinct thalamic and amygdalar pathways, which together contribute to complementary aspects of adaptive threat responses.
    1. Neuroscience

    Molecular and anatomical organization of the dorsal raphe nucleus

    Kee Wui Huang et al.
    The dorsal raphe nucleus contains transcriptionally diverse cell classes that include subtypes of serotonergic neurons with distinct molecular and anatomical signatures.
    1. Neuroscience

    Dopamine neuron ensembles signal the content of sensory prediction errors

    Thomas A Stalnaker et al.
    Dopamine neurons function as an ensemble to signal a multidimensional feature prediction error.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode et al.
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
    1. Neuroscience

    Motor thalamus supports striatum-driven reinforcement

    Arnaud L Lalive et al.
    While the basal ganglia have long been thought to mediate learning through dopamine-dependent striatal plasticity, their regulation of motor thalamus plays an unexpected and critical role in reinforcement.
    1. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.

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