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    1. Developmental Biology

    An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo

    Cora Demler, John Coates Lawlor ... Natasza A Kurpios
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    • Convincing
    1. Cell Biology

    Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

    Guo Yu, Shaoyang Zhang ... Jing Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    • Inadequate
    1. Developmental Biology
    2. Cancer Biology

    MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells

    Kent Riemondy, Xiao-jing Wang ... Rui Yi
    Inhibition of microRNA-203 by oncogenic HRas mutations promotes skin cancer initiation.
    1. Cell Biology

    SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

    Sung Jun Bae, Lisheng Ni ... Xuelian Luo
    The scaffold protein SAV1 counteracts PP2A to activate Hippo kinases.
    1. Developmental Biology

    Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

    Michelle I Lin, Emily N Price ... Leonard I Zon
    Angiopoietin-like proteins signal through notch via receptor interaction and can regulate Notch cleavage/activation.
    1. Stem Cells and Regenerative Medicine

    Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

    Nurul Jannah Mohamed Nasir, Hans Heemskerk ... Lisa Tucker-Kellogg
    Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.
    1. Cancer Biology

    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

    Timothy M Errington, Alexandria Denis ... Lisa Young
    A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration

    Michael RM Harrison, Xidi Feng ... Ching-Ling Lien
    Zebrafish develop cardiac lymphatic vessels along coronary arteries and this vasculature supports scar reduction following severe damage to the myocardium.
    1. Stem Cells and Regenerative Medicine

    Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

    Saleh Omairi, Antonios Matsakas ... Ketan Patel
    The concepts that oxidative muscle fibres cannot be large and that satellite cell number is the major determinant for effective regeneration are fundamentally challenged.