35 results found
    1. Developmental Biology

    Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

    Michelle I Lin et al.
    Angiopoietin-like proteins signal through notch via receptor interaction and can regulate Notch cleavage/activation.
    1. Cell Biology
    2. Developmental Biology

    Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

    Harri Elamaa et al.
    Identification of importance of Angiopoietin-4 (Angpt4) as a first growth factor that initiates venous specification in the peripheral retina, and Angpt4-dependent mechanism for fluid clearance in the mouse retina.
    1. Cell Biology

    Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

    Yu A An et al.
    Gain- and loss-of-function studies highlight the important role for angiopoietin-2 to maintain adipose tissue health during metabolic challenges.
    1. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

    Bo O Zhou et al.
    Normal hematopoietic stem and progenitor cells slow the regeneration of their niche after injury to minimize leakage from the niche vasculature.
    1. Developmental Biology

    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

    Man Chu et al.
    Analyses with genetically engineered mouse models in combination with biochemical approaches reveal a crucial role of the receptor tyrosine kinase Tie2 mediated signals in venogenesis via an Akt mediated regulation of COUP-TFII protein stabilization.
    1. Stem Cells and Regenerative Medicine

    ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

    Wieneke Dijk et al.
    During sustained cold exposure, lipid fuel is specifically directed towards brown adipose tissue, but not white adipose tissue, via cold-induced regulation of Angiopoietin-like 4 (ANGPTL4).
    1. Structural Biology and Molecular Biophysics

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Stem Cells and Regenerative Medicine

    Role of IL-4 in bone marrow driven dysregulated angiogenesis and age-related macular degeneration

    Takashi Baba et al.
    The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.
    1. Cell Biology

    Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

    Fergus M O'Farrell et al.
    Lack of reperfusion of cardiac capillaries, when an upstream artery is unblocked following heart attack, reflects contractile pericytes constricting capillaries and preventing blood flow, implying that cardiac pericytes are a therapeutic target for treating cardiac ischaemia.
    1. Developmental Biology

    Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

    Benjamin R Thomson et al.
    Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.

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