6,852 results found
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Developmental Biology

    A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

    André Dias et al.
    During vertebrate axial extension, the tail bud originates from the activation of a developmental module in a subset of axial progenitors, concurrent but different to gastrulation.
    1. Chromosomes and Gene Expression

    Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

    Srivarsha Rajshekar et al.
    Derepression of transcripts from hypomethylated pericentromeric repeats triggers an innate immune response in an animal model of Immunodeficency, Centromere and Facial anomalies (ICF) syndrome.
    1. Computational and Systems Biology
    2. Neuroscience

    From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

    Sophia Karpenko et al.
    Light-seeking strategies in Zebrafish larvae are dissected using a virtual-reality assay, and these data are used to establish minimal stochastic and neural-circuits models that quantitatively capture this behavior.
    1. Neuroscience

    Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model

    Satoru M Sato, Catherine S Woolley
    Seizures stimulate estrogen synthesis in the brain and acutely inhibiting brain estrogen synthesis suppresses seizures, in both sexes, without additional interventions.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Neuroscience

    Animal Models of Disease: Fly model causes neurological rethink

    Madhumala K Sadanandappa, Mani Ramaswami
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    1. Medicine

    Drug Discovery: From worms to fish to mice

    Guy M Benian, Hyojung J Choo
    An multi-species approach can be used to identify small molecules with properties that might prove useful for the treatment of some neuromuscular diseases.
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    1. Neuroscience

    Inhibition stabilization is a widespread property of cortical networks

    Alessandro Sanzeni et al.
    The strongly coupled theoretical regime describes the function of mouse sensory and motor cortical areas.

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