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Structural Biology and Molecular Biophysics
Identification of a lipid scrambling domain in ANO6/TMEM16F
Kuai Yu et al.
The amino acids that are necessary for phospholipid scrambling by ANO6/TMEM16F can, via domain swapping, confer scrambling activity to the chloride ion channel ANO1 that normally does not scramble phospholipids.
Computational and Systems Biology
Meta-Research: Centralized scientific communities are less likely to generate replicable results
Valentin Danchev et al.
Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
Human Biology and Medicine
Stem Cells: Put to the test
Marites T Woon, Timothy J Kamp
Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.
2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics
Sheena A Josselyn
Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
The Natural History of Model Organisms: Planting molecular functions in an ecological context with
Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
Research: Sci-Hub provides access to nearly all scholarly literature
Daniel S Himmelstein et al.
The availability of almost all articles from toll access journals in the Sci-Hub repository will disrupt scholarly publishing towards more open models.
Research: Gender bias in scholarly peer review
Markus Helmer et al.
Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.
Peer Review: Decisions, decisions
Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences.
Research: Theory, models and biology
Wenying Shou et al.
Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
Extinction Risk: Counting the cost of overfishing on sharks and rays
Darcy Bradley, Steven D Gaines
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