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Structural Biology and Molecular Biophysics
Identification of a lipid scrambling domain in ANO6/TMEM16F
Kuai Yu et al.
The amino acids that are necessary for phospholipid scrambling by ANO6/TMEM16F can, via domain swapping, confer scrambling activity to the chloride ion channel ANO1 that normally does not scramble phospholipids.
Human Biology and Medicine
Stem Cells: Put to the test
Marites T Woon, Timothy J Kamp
Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual’s response to potential new drugs before clinical trials.
Computational and Systems Biology
Meta-Research: Centralized scientific communities are less likely to generate replicable results
Valentin Danchev et al.
Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics
Sheena A Josselyn
Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
The Natural History of Model Organisms: Planting molecular functions in an ecological context with
Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
Research: Sci-Hub provides access to nearly all scholarly literature
Daniel S Himmelstein et al.
The availability of almost all articles from toll access journals in the Sci-Hub repository will disrupt scholarly publishing towards more open models.
Peer Review: Decisions, decisions
Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences.
Research: Gender bias in scholarly peer review
Markus Helmer et al.
Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.
Research: Theory, models and biology
Wenying Shou et al.
Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
Extinction Risk: Counting the cost of overfishing on sharks and rays
Darcy Bradley, Steven D Gaines
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