Intracellular recordings in singing birds and images of synapses in deafened birds provide insights into the neural circuitry that enables songbirds to fine-tune their songs.

A transport mechanism is uncovered in the major drug-efflux system in E. coli involving two remote alternating-access conformational cycles, which could provide the basis for the development of allosteric inhibitors against multidrug resistance.

Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia

A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.

There is surprising functional splitting of major hippocampal GABA cell classes during high-frequency network oscillations that doubles the repertoire of spatio-temporal patterns of GABA release.

The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via combinatorial usage of multiple weak interaction sites.

Super-resolution imaging reveals how the skeleton that supports the outer membrane of axons is assembled during development, and provides an explanation for why this structure preferentially forms in axons but rarely in dendrites.

Deep penetration and transmission of mechanical force to regulate ER functions depends on not only the passive cytoskeletal support, but also the active actomyosin contractility, which is dispensable for mechanotransduction at the plasma membrane.

Repression of gene expression by the histone methyltransferase G9a is guided by two zinc finger proteins that can recognize consensus sequences in DNA.