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    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

    Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Twist is the key to the gating of mechanosensitive ion channel NOMPC

    Jingze Duan, Chen Song
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas J Roberts
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Neuroscience

    Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

    Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

    Xue Chen, Deng Pan ... Yanrui Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

    Nayoung Kim, Sehhoon Park ... Myung-Ju Ahn
    Single-cell RNA sequencing of biopsy samples from advanced-stage lung cancer reveals tumor and immune cell features associated with response to immune checkpoint therapy.
    1. Structural Biology and Molecular Biophysics

    Conservation of the cooling agent binding pocket within the TRPM subfamily

    Kate Huffer, Matthew CS Denley ... Kenton J Swartz
    The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.
    1. Neuroscience

    Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cancer Biology

    The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

    Ting Cai, Bei Zhang ... Zhihao Wu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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