1,802 results found
    1. Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al.
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.
    1. Computational and Systems Biology

    A computational interactome and functional annotation for the human proteome

    José Ignacio Garzón et al.
    A machine-learning approach is used to predict 1.35 million interactions for 85% of the human proteome.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins

    Sondos Samandi et al.
    Conventional annotations of coding sequences have missed thousands of short open-reading frames encoding proteins that are conserved and with specific functions.
  1. eLife latest: How readers are using annotations on our website

    We take a look at how readers are already using the annotation tool, Hypothesis, on our website.
  2. Podcast team working at the Sprint

    Innovation Sprint: A podcast

    A sneak peek of what happened at the eLife Innovation Sprint 2019.
  3. Innovation Sprint 2019

    Innovation Sprint 2019: Project roundup

    From web tools to drive forward research discovery, citation and evaluation, to literature curation and knowledge extraction, we showcase the projects developed at this year’s Innovation Sprint.
  4. Innovation: Collaboration and creativity at the heart of the eLife Innovation Sprint 2018

    On May 10 and 11, 62 community members designed and developed for open science at the eLife Innovation Sprint.
  5. eLife Latest: How publishers are coming on board with open annotations

    We explore how publishers are adopting the newly customised Hypothesis annotation platform to promote scientific discussion online.
  6. A team gather around a laptop

    eLife Innovation Sprint 2018: Project roundup

    From gamification of sample-size identification to a decentralised lab notebook, we showcase the projects developed at the eLife Innovation Sprint.
  7. Apply now for the eLife Innovation Sprint 2019

    The second edition of the Innovation Sprint will take place September 4-5 in Cambridge, UK.

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