An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
Using a cross-species phenotypic drug discovery pipeline, compounds promoting rod photoreceptor survival in zebrafish and mouse models of retinitis pigmentosa were identified, evidence of additive effects of paired compounds and inhibition of PARP-dependent cell death suggest novel therapeutic strategies.
Elizabeth M Steenkiste, Jason D Berndt ... Jonathan A Cooper
Epithelial cells coordinate integrin signaling with protrusion via a two-protein module, with one protein defining localization and downstream signaling, the other serving as a phosphorylation switch and providing negative feedback.
Savannah G Brovero, Julia C Fortier ... Michelle N Arbeitman
Analyses of fru P1 neurons that express dpr/DIP genes reveal roles for subsets of neurons in courtship, and the roles of Dpr/DIPs and the sex hierarchy in neuroanatomical sexual dimorphism.
Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
Nathalie Feiner, Illiam SC Jackson ... Tobias Uller
A comparative and experimental research refutes the controversial hypothesis that plasticity played a major role in the convergent evolution of Anolis ecomorphs.
Lizards that live in the Greater Antilles exploit a large range of skeletal variations to adapt to similar habitats, in defiance of the theory of plasticity-led evolution.
ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
DAZL promotes male fertility by enhancing the protein expression of thousands of genes to facilitate expansion and differentiation of transit-amplifying spermatogonia in the testes.
