7,944 results found
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet et al.
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush et al.
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang et al.
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Microbiology and Infectious Disease

    The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

    Anat Melamed et al.
    The human leukemia virus HTLV-1 causes abnormal chromatin looping in tens of thousands of infected T cell clones in each host, and abnormal host transcription both flanking the integrated provirus and at distant loci in cis.
    1. Structural Biology and Molecular Biophysics

    Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

    Sojin An et al.
    Structural and biochemical studies of Kap123 revealed the mechanisms by which Kap123 recognizes H3- and H4-NLSs through two lysine-binding pockets and by which evolutionarily conserved diacetylation of H4-NLS facilitates Kap123-H3-NLS mediated nuclear translocation.
    1. Neuroscience

    Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses

    Quynh-Anh Nguyen et al.
    Electrophysiological recordings reveal domains within the extracellular and intracellular region of neuroligin important for specifying and carrying out its function at inhibitory synapses respectively.
    1. Epidemiology and Global Health

    Malaria: Age, exposure and immunity

    Michael White, James Watson
    The acquisition of immunity to malaria by an individual depends on their age and the number of infectious mosquito bites they have received.
    Insight
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  1. Scientific Publishing: Recognizing the importance of new tools and resources for research

    Randy Schekman et al.
    eLife is introducing a new article type—called Tools and Resources—to highlight new experimental techniques, datasets, software tools and other resources.
    Editorial
    Available as:
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  2. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.

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