12,371 results found
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells

    Ana Filipa Domingues et al.
    Histone acetyl-transferase Kat2a preserves leukemia stem cells through frequent transcriptional firing of metabolic and regulatory gene promoters and maintenance of a largely invariant self-renewal program.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen et al.
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

    Cheen Euong Ang et al.
    lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
    1. Evolutionary Biology

    Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

    Ana B Tinoco et al.
    Starfish feed by everting their stomach out of their mouth over prey and, interestingly, this unusual feeding mechanism is inhibited by substances similar to hormones that regulate feeding in humans.
    1. Cell Biology
    2. Neuroscience

    The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

    Ana Rita Costa et al.
    The axonal cytoskeletal contains an actomyosin-II network that controls circumferential axonal contraction and expansion with the potential of regulating fluctuations in diameter during action potential firing, trafficking, and degeneration.
    1. Structural Biology and Molecular Biophysics

    Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

    Sojin An et al.
    Structural and biochemical studies of Kap123 revealed the mechanisms by which Kap123 recognizes H3- and H4-NLSs through two lysine-binding pockets and by which evolutionarily conserved diacetylation of H4-NLS facilitates Kap123-H3-NLS mediated nuclear translocation.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen et al.
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Cancer Biology

    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism

    Krystal Ann Orlando et al.
    BRG1 loss drives initiation and progression in human cancers through changes in specific differentiation programs in an AP-1-dependent manner.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

    Ana J Caetano et al.
    Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.
    1. Neuroscience

    A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

    Ana C Sias et al.
    The bidirectional orbitofrontal cortex-basolateral amygdala circuit helps us to learn the details of predicted rewarding events and then to use that information to make good reward pursuit decisions.

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