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    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov, Petrus Van der Auwera ... Alexander Gottschalk
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Neuroscience

    Inhibitory control of frontal metastability sets the temporal signature of cognition

    Vincent Fontanier, Matthieu Sarazin ... Emmanuel Procyk
    Single unit recordings in monkeys and biophysical modelling demonstrate that local inhibitory-controlled metastable neural states specify the temporal organization of cognitive functions in frontal areas.
    1. Cell Biology
    2. Developmental Biology

    Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish

    Mylene Lancino, Sara Majello ... Anne Schmidt
    Emergence of hematopoietic stem cells from an aortic component is a unique phenomenon of cell extrusion, with no equivalent in cell biology, and which is adapted to environmental constraints exerted by endothelial cells and hemodynamics forces.
    1. Developmental Biology

    Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny

    Michèle Romanos, Guillaume Allio ... Bertrand Bénazéraf
    Spatial variations of transcription factor expression regulate the choice of progenitors to stay in their niche or to migrate into neural and mesodermal tissues.
    1. Neuroscience

    Ventral striatum dopamine release encodes unique properties of visual stimuli in mice

    L Sofia Gonzalez, Austen A Fisher ... J Elliott Robinson
    Dopamine release in the nucleus accumbens in mice encodes the rate and magnitude of rapid environmental luminance changes rather than visual stimulus novelty or threat intensity.
    1. Developmental Biology

    Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

    Almary Guerra, Raoul FV Germano ... Sven Reischauer
    A discovery of two previously unknown, molecularly distinct fields of cardiac progenitors in zebrafish provides evidence for cardiac laterality prior to the emergence of cardiac septation and allows novel insights into cardiac development and disease.
    1. Neuroscience

    Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

    J Elliott Robinson, Gerard M Coughlin ... Viviana Gradinaru
    Heterozygous Nf1 knockout mice exhibit distinct dopaminergic phenotypes in vivo, as revealed by the genetically encoded dopamine sensor dLight1, patch clamp electrophysiology, optogenetics, and novel viral tools for morphological analysis.
    1. Developmental Biology
    2. Neuroscience

    Adrenergic activation modulates the signal from the Reissner fiber to cerebrospinal fluid-contacting neurons during development

    Yasmine Cantaut-Belarif, Adeline Orts Del'Immagine ... Pierre-Luc Bardet
    The Reissner fiber in the cerebrospinal fluid is required for a signal integrated by developing sensory neurons and modulated by catecholamines to control the embryo posterior axis morphogenesis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
    1. Developmental Biology

    Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

    Zoe F Mann, Héctor Gálvez ... Nicolas Daudet
    A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.