Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.

Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.

DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.

Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.

The molecular mechanism that candidalysin uses to perforate membranes is unraveled, which opens the door to the rational design of inhibitors against candidiasis.

Applying bioorthogonal chemistry to the zebrafish/Mycobacterium marinum model of tuberculosis reveals that the virulence lipid PDIM must spread into epithelial cells in order for mycobacteria to establish infection.

N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.