2,306 results found
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.
    1. Neuroscience

    Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

    Sarah Cantor et al.
    An agonist antibody to MuSK, delivered after disease onset, decreases the loss of neuromuscular synapses, improves motor function and extends the lifespan of ALS mice.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A potent human neutralizing antibody Fc-dependently reduces established HBV infections

    Dan Li et al.
    A novel and potent receptor-binding-blockage human neutralizing antibody prevents HBV infection, and suppresses HBV infection therapeutically in HBV-infected mice.
    1. Immunology and Inflammation

    The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

    Fu-Lien Hsieh, Matthew K Higgins
    The structure of a human antibody in which the variable loops position a human protein LAIR1 for antigen recognition, reveals a novel and indirect mode of antibody function.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Computationally-driven identification of antibody epitopes

    Casey K Hua et al.
    The combination of computational modeling and protein design can reveal key determinants of antibody‚Äďantigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

    Paola Favuzza et al.
    The structure of the promising malaria blood-stage vaccine candidate antigen PfCyRPA and the characterization of a protective epitope are facilitating research on its essential role in parasite invasion, and will guide future epitope-focused vaccine design.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

    Felix Horns et al.
    A comprehensive map of patterns of class switching reveals how antibodies of every class are created in humans.
    1. Immunology and Inflammation

    The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

    Heather D Marshall et al.
    Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

    Victor Ovchinnikov et al.
    Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structural basis for germline antibody recognition of HIV-1 immunogens

    Louise Scharf et al.
    Structural and computational analyses of germline antibody/HIV-1 gp120 complexes provide both general principles relevant to the unusual evolution of potent CD4-binding site antibodies and guidelines for structure-based immunogen design.

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