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    1. Cell Biology
    2. Developmental Biology

    The ESCRT machinery regulates retromer-dependent transcytosis of septate junction components in Drosophila

    Hendrik Pannen, Tim Rapp, Thomas Klein
    A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely C Matteucci, Patricia A Assis ... Ricardo T Gazzinelli
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier

    Fu Li, Gregory Artiushin, Amita Sehgal
    Metabolites, such as acylcarnitines, accumulate in Drosophila heads when endocytosis is blocked and reflects an increased need for sleep.
    1. Neuroscience

    Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

    Zhengming Tian, Feiyang Jin ... Jia Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang, Wenju Sun ... Jian Yan
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Genetics and Genomics
    2. Neuroscience

    Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age

    Jessica M Sidisky, Daniel Weaver ... Daniel Babcock
    Maintaining synaptic structure and function over time requires continuous signaling from pathways that are crucial for synapse development.
    1. Immunology and Inflammation

    Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Different serotonergic neurons regulate appetite for sucrose and hunger for proteins

    Katharina Dorn, Magdalena Gompert ... Henrike Scholz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Plant Biology

    The phytoplasma SAP54 effector acts as a molecular matchmaker for leafhopper vectors by targeting plant MADS-box factor SVP

    Zigmunds Orlovskis, Archana Singh ... Saskia A Hogenhout
    Phytoplasma effector SAP54 hijacks previously unknown MADS-box protein roles in plant-insect interactions by modulating plant biotic stress responses to male leafhoppers and facilitating female attraction and reproduction on male-exposed leaves.
    1. Neuroscience

    Pain persists in mice lacking both Substance P and CGRPα signaling

    Donald Iain MacDonald, Monessha Jayabalan ... Alexander Chesler
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
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