6,281 results found
    1. Neuroscience

    PVN-mPFC OT projections modulate pup-directed pup care or attacking in virgin mandarin voles

    Lu Li, Yin Li ... Fadao Tai
    Activation of oxytocin (OT) neurons in the paraventricular nucleus or their projections to medial prefrontal cortex or periphery OT administration facilitated pup caring and inhibited infanticide, while inhibitions of these neurons and projections promoted infanticide.
    1. Developmental Biology

    Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes

    Nick Riddiford, Gerhard Schlosser
    RNA sequencing of the African clawed frog has identified hundreds of putative direct Six1 and Eya1 target genes, including transcriptional regulators of neuronal progenitors and neuronal/sensory differentiation.
    1. Neuroscience

    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

    Magda L Atilano, Sebastian Grönke ... Linda Partridge
    Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.
    1. Microbiology and Infectious Disease

    Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors

    Yuho Murata, Tsubasa Nishi ... Masao Yuda
    Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun, Yimin Fang ... Andrzej Bartke
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    Simon Perrin, Maria Ethel ... Céline Colnot
    A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication

    Neale J Harrison, Elizabeth Connolly ... Alicia Hidalgo
    Neuronal Ia-2 and glial Kon coordinate an injury-response insulin relay that restores glial cell populations and induces neural stem cells from glia, enabling central nervous system regeneration.
    1. Immunology and Inflammation
    2. Medicine

    Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

    Shubhanshi Trivedi, Daniel Labuz ... Daniel T Leung
    Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
    1. Chromosomes and Gene Expression

    Chromatin endogenous cleavage provides a global view of yeast RNA polymerase II transcription kinetics

    Jake VanBelzen, Bennet Sakelaris ... Jason H Brickner
    An alternative method for mapping RNA polymerase II occupancy over the genome provides new insights into the kinetics and molecular mechanism of transcription.
    1. Medicine

    Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    Sindre Lee-Ødegård, Marit Hjorth ... Kåre Inge Birkeland
    Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.

Refine your results by:

Type
Research categories