Blood-borne factors contribute to changes in the circadian transcriptome with age.

Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.

Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.

A common genomic deletion in various human cancers disrupts mitochondrial protein homeostasis in a way that might be targeted by existing drugs.

Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.

The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.

Resting natural killer cells promote the progress of colon cancer liver metastasis (CCLM), which may be exploited for novel strategies to improve therapeutic outcomes for patients with CCLM.

Accumulation of succinate during the in vitro modeling of embryonic stem cell state transition critically regulate cell fate.

Regulatory T cell suppress cytotoxic T cells in autoimmunity and cancer by taking up IL-2.

In vivo and in vitro experiments confirm the conspicuous antineoplastic efficacy of NIR-III photothermal therapy under the premise of ensuring biosafety.