66 results found
    1. Neuroscience

    Correction of amblyopia in cats and mice after the critical period

    Ming-fai Fong et al.
    Visual impairment caused by monocular deprivation early in life can be reversed rapidly at older ages by temporarily blocking all activity in the non-deprived eye.
    1. Medicine

    Risk of motor vehicle collisions after methadone use

    Ya-Hui Yang et al.
    Methadone maintenance treatment (MMT) can alleviate opioid dependence, however, drivers receiving MMT were at high risk of motor vehicle collisions in the present study, particularly the first 90 days of MMT.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Neuroscience

    Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

    Yongzhi Huang et al.
    Increased theta/alpha band activities within the habenula area and the prefrontal cortex, as well as the increased synchrony between the two structures in the same frequency band can serve as an indicator for negative emotions in humans.
    1. Neuroscience

    Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability

    Laifu Li et al.
    Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu et al.
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Neuroscience

    Antidepressants: Where ketamine and dopamine collide

    David J Marcus, Michael R Bruchas
    Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.
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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar et al.
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Neuroscience

    Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition

    Zachariah Bertels et al.
    In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
    1. Medicine
    2. Neuroscience

    Self-blinding citizen science to explore psychedelic microdosing

    Balázs Szigeti et al.
    The anecdotally reported benefits of psychedelics microdosing can be explained by the placebo effect.

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