1,194 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating influenza antigenic dynamics with molecular evolution

    Trevor Bedford et al.
    Combined antigenic and genetic analysis shows that different strains of the human influenza virus display dramatically different rates of antigenic drift, and that these differences have a significant impact on the number of new infections in each flu season.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston et al.
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

    Juhye M Lee et al.
    Single viral mutations can escape polyclonal human immunity to influenza hemagglutinin, but different mutations escape the immunity of different people.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen et al.
    The abundance and complex genetic diversity of swIAV were documented and the zoonotic potential evaluated.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris et al.
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The global antigenic diversity of swine influenza A viruses

    Nicola S Lewis et al.
    Swine populations worldwide are sporadically infected by influenza viruses from humans and birds leading to geographically heterogeneous swine influenza virus populations that pose epizootic and pandemic threats.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolution of cytokine production capacity in ancient and modern European populations

    Jorge Domínguez-Andrés et al.
    Neolithic was a turning point for immune responses in Europeans, favoring tolerance against intracellular pathogens, promoting inflammation against extracellular microbes, and being related to current auto-immune diseases.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stochastic processes constrain the within and between host evolution of influenza virus

    John T McCrone et al.
    An analysis of influenza viruses from naturally infected people suggests a tight transmission bottleneck and little positive selection within hosts.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Seasonal Influenza: The challenges of vaccine strain selection

    Amanda C Perofsky, Martha I Nelson
    New measures of influenza virus fitness could improve vaccine strain selection through more accurate forecasts of the evolution of the virus.
    Insight
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