140 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Heterogeneous absorption of antimicrobial peptide LL37 in Escherichia coli cells enhances population survivability

    Mehdi Snoussi et al.
    A rapid absorption and retention of antimicrobial peptides by dead Escherichia coli cells can increase the survivability of the cell population in a "cooperative" fashion.
    1. Biochemistry and Chemical Biology

    Genome-wide effects of the antimicrobial peptide apidaecin on translation termination in bacteria

    Kyle Mangano et al.
    Inhibition of bacterial protein synthesis by an antimicrobial peptide apidaecin triggers translation arrest at the stop codons, ribosome queuing and pervasive stop codon readthrough.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Cancer Biology
    2. Developmental Biology

    The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

    Jean-Philippe Parvy et al.
    Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in Drosophila.
    1. Immunology and Inflammation

    Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

    Mark Austin Hanson et al.
    While antimicrobial cocktails are highly effective for defence against pathogenic microbes, the innate immune response may instead employ highly specific peptidic antibiotics to combat certain natural enemies.
    1. Structural Biology and Molecular Biophysics

    Effect of helical kink in antimicrobial peptides on membrane pore formation

    Alzbeta Tuerkova et al.
    Proline/glycine kink in the helical peptides affects the peptide ability to form membrane pores by stabilising toroidal pore structures but disrupting barrel-stave pore structures.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks et al.
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Structural Biology and Molecular Biophysics

    Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

    Ivan KH Poon et al.
    A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-autonomous immune response regulates stress signaling during hypertrophy

    Robert Krautz et al.
    The immune effector Drosomycin buffers stress signaling in hypertrophic salivary glands to inhibit their disintegration, detection by the cellular immune response, and promotes further overgrowth.

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