89 results found
    1. Cancer Biology
    2. Developmental Biology

    The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

    Jean-Philippe Parvy et al.
    Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in Drosophila.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Heterogeneous absorption of antimicrobial peptide LL37 in Escherichia coli cells enhances population survivability

    Mehdi Snoussi et al.
    A rapid absorption and retention of antimicrobial peptides by dead Escherichia coli cells can increase the survivability of the cell population in a "cooperative" fashion.
    1. Immunology and Inflammation

    Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach

    Mark Austin Hanson et al.
    While antimicrobial cocktails are highly effective for defence against pathogenic microbes, the innate immune response may instead employ highly specific peptidic antibiotics to combat certain natural enemies.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Structural Biology and Molecular Biophysics

    Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

    Ivan KH Poon et al.
    A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks et al.
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Tuberculosis: Breaking down walls

    Moagi Tube Shaku, Bavesh Davandra Kana
    A better understanding of the mechanisms underpinning the growth of mycobacteria could help identify targets for new antibiotics.
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    1. Cell Biology
    2. Immunology and Inflammation

    Diverse stimuli engage different neutrophil extracellular trap pathways

    Elaine F Kenny et al.
    NETs induction, a central component of the innate immune response, utilises assorted signalling pathways as demonstrated through the analysis of healthy and patient neutrophils treated with five distinct stimuli.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

    James E Gomez et al.
    Mutations in several components of a bacterial ribosome are shown to broadly decrease antibiotic and stress sensitivity, and readily accessible reversion mutations allow these ribosomal mutations to serve as stepping stones to high level antibiotic resistance.

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