209 results found
  1. November 2015

    Episode 25: November 2015

    In this episode we hear about deep-sea bacteria, cigarette smoke and lung disease, antibiotic resistance, unconscious perception, and the benefits of sleep.
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    COVID-19: A Collection of Articles

    Edited by Diane M Harper et al.
    eLife has published the following articles on SARS-CoV-2 and COVID-19.
  2. March 2016

    Episode 28: March 2016

    In this episode we hear about aging, artificial fingertips, ancient DNA, antibiotic resistance and dengue fever.
  3. December 2013

    Episode 7: December 2013

    In this episode we hear about drug resistance, severe brain damage, sugar versus sweetener, public goods dilemmas, and the evolution of the machinary that makes proteins in cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

    Ali H Alghamdi et al.
    Study of TbAQP2 adaptations and substrate interactions shows how this aquaglyceroporin enables cellular entry of large antimicrobial agents in Trypanosoma brucei.
    1. Evolutionary Biology

    Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

    José Antonio Escudero et al.
    The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein domains.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

    Timothy J de Wet et al.
    A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.
    1. Microbiology and Infectious Disease

    Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa

    Dominique H Limoli et al.
    Pseudomonas aeruginosa coordinates invasion and destruction of Staphylococcus aureus communities by modulating single-cell and collective motility.
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao et al.
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.
    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.

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