5 results found
    1. Neuroscience

    KIT ligand protects against both light-induced and genetic photoreceptor degeneration

    Huirong Li et al.
    A combination of in vitro and in vivo experiments demonstrate a cell-autonomous role of the KIT ligand/KIT signaling pathway in protecting retinal photoreceptor cells from environmentally or genetically caused degeneration.
    1. Immunology and Inflammation

    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

    Hui Che et al.
    A novel IVDD mechanism that involves p16 is demonstrated and theoretical evidence is provided for effective methods to downregulate p16 and so reverse IVDD.
    1. Neuroscience

    Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

    Jingjing Sherry Wu et al.
    Based on the animal’s recent history of sound exposure, cholinergic auditory brainstem neurons dynamically regulate dopamine synthesis for inhibitory feedback to the inner ear.
    1. Cancer Biology

    Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

    Harihar Basnet et al.
    Development and application of highly sensitive in situ transcriptomics method, Flura-seq, in identifying dynamic organ-specific transcriptomes in early stage breast cancer metastasis have been described.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

    Markus Gressler et al.
    Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.

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