William HK Schilling, Podjanee Jittamala ... Nicholas J White
Pharmacometric evaluation of viral clearance rates based on frequent oropharyngeal sampling is a highly efficient and well-tolerated method of assessing and comparing SARS-CoV-2 antiviral therapeutics in vivo.
The identification of a conserved α-helical domain in monkeypox virus H3 protein as critical for heparan sulfate binding unveils a novel therapeutic target, validated through AI and molecular dynamics simulations, offering potential for broad-spectrum antiviral development.
The interplay of the host metabolic reprogramming, its negative association with antiviral biological signaling pathways and the IFN-mediated host antiviral mechanism during Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) infection could provide attractive options for therapeutic intervention of CCHF.
Laura C Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.
Edward R Kastenhuber, Marisa Mercadante ... Lewis Cantley
Factor Xa and thrombin cleavage activate SARS-CoV-2 spike, widening the scope of host proteases involved in coronavirus entry and demonstrating the potential for dual anticoagulant/antiviral drugs.
The anti-HIV drug lenacapavir breaks the HIV capsid by stabilising regions of low curvature at the expense of maintaining a closed shell, leading to loss of viral DNA synthesis and inhibition of infection.
