scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.

Tim-3 promotes the ubiquitination and degradation of NF90, a novel virus sensor, and negatively regulates the NF90-SG pathway-mediated antiviral innate immunity.

Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.

A MRI study of virally infected CNS demonstrates the utility of MRI in detecting the earliest pathological events and studying pathogen-specific T cells at the level of single cell as well as the therapeutic potential of antiviral T cells.

AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.

Plant autophagy contributes to antiviral defense against geminiviruses by targeting one or more viral proteins for degradation.

Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.

Hepatitis C virus evades IRF1-dependent intrinsic antiviral immunity by exploiting cyclophilin A and its regulation of PKR.

Ebola virus VP35 protein evades host antiviral immunity by interacting with STING to sequester IRF3 into inclusion bodies and inhibit type I interferon production.

Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.