1,044 results found
    1. Immunology and Inflammation

    Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

    Wei Liu et al.
    CypA boosts RIG-I-mediated antiviral immune responses via enhancing K63-linked ubiquitination of RIG-I and inhibiting K48-linked ubiquitination of MAVS.
    1. Plant Biology

    Autophagy functions as an antiviral mechanism against geminiviruses in plants

    Yakupjan Haxim et al.
    Plant autophagy contributes to antiviral defense against geminiviruses by targeting one or more viral proteins for degradation.
    1. Chromosomes and Gene Expression

    Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases

    Yujia Cai et al.
    Lentiviral protein transduction offers a new approach for administration of custom-designed nucleases, leading to high-efficacy targeted gene editing and reduced off-target activity after virus-directed delivery of programmable nuclease proteins.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors

    Yujia Cai et al.
    Building on previous work (Cai et al., 2014), HIV-derived lentiviral vectors are harnessed to insert user-defined genes into a safe locus in the genome of human stem cells.
    1. Immunology and Inflammation

    AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

    Edward T Schmid et al.
    AXL enables the priming of the antiviral adaptive immune response by limiting the production of type I interferons in dendritic cells.
    1. Microbiology and Infectious Disease

    Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

    Edward JD Greenwood et al.
    A comprehensive whole cell proteomic map describing expression time courses of >6,500 viral and cellular proteins during HIV infection identifies Vif-dependent antagonism of key cellular phosphatase PP2A.
    1. Immunology and Inflammation

    Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

    Shuaijie Dou et al.
    Tim-3 promotes the ubiquitination and degradation of NF90, a novel virus sensor, and negatively regulates the NF90-SG pathway-mediated antiviral innate immunity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

    Joshua R Kane et al.
    A peptide derived from BK and JC polyomavirus protein VP2/3 inhibits viral infection by targeting a binding site in the pore of polyomavirus VP1 pentamers, enabling future VP1-targeted therapeutic strategies.
    1. Cell Biology
    2. Immunology and Inflammation

    RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

    Ziwei Yang et al.
    RTN3 is upregulated upon RNA viral infection, in turn suppresses antiviral responses by impairing TRIM25-mediated RIG-I K63-linked polyubiquitination and decreases neutrophil populations and inflammatory infiltration, representing a novel inflammatory resolution.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

    Joseph Shaw et al.
    Exploiting virus-encoded ion channels as drug targets drove a multi-faceted approach to deriving potent small molecules targeting HCV p7, simultaneously providing new insights into its fundamental biology.

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