6,677 results found
    1. Ecology
    2. Evolutionary Biology

    Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

    Susanne RK Zajitschek et al.
    Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.
    1. Cell Biology
    2. Physics of Living Systems

    A physical mechanism of TANGO1-mediated bulky cargo export

    Ishier Raote et al.
    TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

    Iga Kucharska et al.
    A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.
    1. Neuroscience

    The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice

    Mattia Aime et al.
    The frontal associative cortex promotes fear learning by non-linearly integrating Gaussian noise in between conditioning trials with the help of basolateral amygdala inputs.
    1. Neuroscience

    Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

    Vanessa Lage-Rupprecht et al.
    The essential role of presynaptic NMDA receptors for granule cell GABAergic output elucidates the function of reciprocal spines in recurrent and possibly lateral inhibition of mitral cells during olfactory processsing.
    1. Neuroscience

    How many neurons are sufficient for perception of cortical activity?

    Henry WP Dalgleish et al.
    Targeted optogenetic activation of small ensembles of neurons is sufficient to trigger a behavioral report while recruiting matched network suppression, suggesting exquisite sensitivity despite network mechanisms that maintain sparseness.
    1. Cell Biology
    2. Developmental Biology

    Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

    Yan Xiong et al.
    Primary cilia on endothelial cells are required for VEGF-A/ VEGFR2-dependent signaling, islet vascularization and, consequently, nutrient delivery and insulin disposal.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Chromosomes and Gene Expression

    Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length

    Shanaya Shital Shah et al.
    The dsDNA-dependent motor protein Rdh54 antagonizes Rad51-Rad54-mediated D-loop formation during homologous recombination and restricts the length of D-loops.

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