Although primary sensory neuron-derived calcitonin gene-related peptide (CGRP) contributes to the processing of pain messages, an understudied population of dorsal horn CGRP-expressing interneurons also contributes to the processing of mechanical sensitivity.
HIPPO signaling antagonizes the apical domain of polarized cells, driving cell internalization, regulated gene expression, and cell fate change during formation of pluripotent stem cell progenitors in the mouse embryo.
Sequential introduction of transcription factors enables large-scale generation of induced motor neurons (iMNs) from human somatic cells, and transplantation of iMNs exhibit therapeutic effects in spinal cord injury model.
Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.
The symbiotic relationship between Hydra and Chlorella is driven by metabolic co-dependence and characterized by changes in the photobiont genome in terms of lack of genes essential in free-living algae.