1,358 results found
    1. Developmental Biology

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo et al.
    A common mechanism might regulate the communal death of cells in flies and mammals.
    1. Stem Cells and Regenerative Medicine

    Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

    Lucy LeBlanc et al.
    During ES cell differentiation, Yap1 directly regulates apoptosis-related genes like Bcl-2 and Mcl-1 to attenuate apoptosis and promote cell survival to allow for successful cell fate changes.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita et al.
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

    Christopher Duncan-Lewis et al.
    Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.
    1. Cancer Biology
    2. Cell Biology

    A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis

    Jesusa Capera et al.
    The association of caveolin with the potassium channel Kv1.3 fine-tunes cell survival and apoptosis.
    1. Cell Biology
    2. Immunology and Inflammation

    Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

    Snehlata Kumari et al.
    The adaptor proteins FADD and TRADD play an important role in the Sharpin-dependent anti-apoptosis signaling pathway in keratinocytes and regulate skin homeostasis.
    1. Chromosomes and Gene Expression

    The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer

    Eric Wang et al.
    TRIM33 performs an essential function in B cell acute lymphoblastic leukemia through an association with a single cis element.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

    Zhaowei Wang et al.
    A picorna-like virus promotes the accumulation of caspase-cleaved drosophila inhibitor of apoptosis 1 by inducing the degradation of NTAN1, a key N-end rule degradation pathway component, leading to apoptosis inhibition and viral replication enhancement.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

    Mable Lam et al.
    Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.
    1. Cell Biology

    IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact

    Benjamin Bonneau et al.
    IRBIT and the Bcl-2 homolog Bcl2l10 form a complex at the endoplasmic reticulum that controls Ca2+ signaling, however IRBIT turns into an apoptosis facilitator following stress and inhibits anti-apoptotic activity of Bcl2l10.

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