13 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A near atomic structure of the active human apoptosome

    Tat Cheung Cheng et al.
    A cryo-electron microscopy model of the active human apoptosome illuminates how this "wheel of death" binds the protease procaspase-9 to initiate programmed cell death.
    1. Ecology
    2. Evolutionary Biology

    Comparative genomics explains the evolutionary success of reef-forming corals

    Debashish Bhattacharya et al.
    The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.
    1. Neuroscience

    Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

    Silvia Ripamonti et al.
    Perturbation of oxytocin signaling causes alterations that may be causally involved in the etiology of oxytocin-related neurobehavioral disorders.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

    Nicholas R Ader et al.
    Correlative microscopy and electron cryo-tomography on apoptotic HeLa cells reveal remodeling of outer and inner mitochondrial membranes, Bax cluster ultrastructure and ATP synthase reorganization in ruptured mitochondria.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

    Edoardo D'Imprima et al.
    The pilus extrusion/DNA uptake system of Thermus thermophilus contains a 13-mer of the 757-residue PilQ protein and a tightly bound protein outside the outer membrane with a role in DNA binding.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen et al.
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Developmental Biology

    Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak

    Jason Karch et al.
    Molecular pathways controlling autophagic cell death are regulated at the level of the lysosome through the activity of the pro-death Bcl-2 family member Bax/Bak.
    1. Cell Biology

    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

    Alexandra M Whiteley et al.
    Stimulation of cells with a mitochondria-depolarizing mitogen reveals a requirement for UBQLN1 expression in maintaining protein synthesis levels during cell cycle entry.
    1. Developmental Biology

    Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration

    Francisco J Barrionuevo et al.
    The vertebrate testis-determining gene, Sox9, also controls adult testis maintenance in mammals, acting redundantly with its paralog Sox8.
    1. Cell Biology
    2. Immunology and Inflammation

    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

    Junghyun Lim et al.
    Autophagy is critical for the turnover of inflammatory signaling complexes containing RHIM-domain proteins.

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