103 results found
    1. Neuroscience

    Pro-social behavior in rats is modulated by social experience

    Inbal Ben-Ami Bartal, David A Rodgers ... Peggy Mason
    Rats show socially selective helping behavior based on familiarity with the type of rat, but not necessarily the individual rat.
    1. Neuroscience

    Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

    Yoshinori Aso, Divya Sitaraman ... Gerald M Rubin
    Output neurons in the mushroom body of the fruit fly brain encode the positive or negative survival value of stimuli, enabling insects to choose adaptive approach and avoidance behaviors through associative learning.
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut, Weiqing Wang ... Chris Sander
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
    1. Neuroscience

    The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures

    Román A Corfas, Leslie B Vosshall
    Female mosquitoes are exquisitely sensitive to human body heat, and the TRPA1 gene is required to focus their attraction toward thermal stimuli resembling warm-blooded hosts.
    1. Neuroscience

    Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity

    Christopher M Ciarleglio, Arseny S Khakhalin ... Carlos D Aizenman
    The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.
    1. Neuroscience

    Modulation of anxiety and fear via distinct intrahippocampal circuits

    Elif Engin, Kiersten S Smith ... Uwe Rudolph
    The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
    1. Neuroscience

    Quantitative neuroanatomy for connectomics in Drosophila

    Casey M Schneider-Mizell, Stephan Gerhard ... Albert Cardona
    A new method that uses the cellular neuroanatomy of neuronal connectivity to quickly and robustly reconstruct neuronal circuits in Drosophila from large electron microscopy volumes.
    1. Neuroscience

    Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    The enzyme PKMzeta is crucial for the maintenance of long-term memories, but a closely related enzyme provides a back-up should PKMzeta fail, thus explaining the controversy over why deleting the gene for PKMzeta may not appear to impair memory.
    1. Computational and Systems Biology
    2. Ecology

    Place recognition using batlike sonar

    Dieter Vanderelst, Jan Steckel ... Marc W Holderied
    Echolocating bats may recognize locations in the environment (and navigate to them) by remembering the specific echo signature of those locations.
    1. Neuroscience

    Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

    Shanna L Resendez, Piper C Keyes ... Brandon J Aragona
    The neural mechanisms that underlie the maintenance of social bonds between prairie voles suggest that social support networks may be a powerful way of treating addiction.

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