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    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Computational and Systems Biology

    Learning predictive cognitive maps with spiking neurons during behavior and replays

    Jacopo Bono, Sara Zannone ... Claudia Clopath
    Predictive cognitive maps can be learned during behavior and replays using in spiking neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Mice in a labyrinth show rapid learning, sudden insight, and efficient exploration

    Matthew Rosenberg, Tony Zhang ... Markus Meister
    Mice exploring a labyrinth freely for the first time learn a complex action sequence after a handful of rewards, exhibiting a learning rate 1000-fold higher than in commonly-used paradigms.
    1. Neuroscience

    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    J Daniel Obray, Erik T Wilkes ... L Judson Chandler
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Quantitative neuroanatomy for connectomics in Drosophila

    Casey M Schneider-Mizell, Stephan Gerhard ... Albert Cardona
    A new method that uses the cellular neuroanatomy of neuronal connectivity to quickly and robustly reconstruct neuronal circuits in Drosophila from large electron microscopy volumes.
    1. Neuroscience

    Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

    Katherine R Cording, Emilie M Tu ... Helen S Bateup
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut, Weiqing Wang ... Chris Sander
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Neuroscience

    Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations

    Hugo Malagon-Vina, Stéphane Ciocchi, Thomas Klausberger
    A novel behavioural paradigm reveals how neurons in the ventral hippocampus dynamically adapt their firing activity after the introduction of an anxiogenic location.
    1. Evolutionary Biology

    A meta-analysis of the association between male dimorphism and fitness outcomes in humans

    Linda H Lidborg, Catharine Penelope Cross, Lynda G Boothroyd
    While men’s mating success is predicted both by their strength/muscularity, voice pitch, height, and testosterone levels, their reproductive output is only predicted by strength/muscularity.