882 results found
    1. Developmental Biology
    2. Neuroscience

    The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

    Joseph G Duman et al.
    The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
    1. Neuroscience

    Neurexin and Neuroligin-based adhesion complexes drive axonal arborisation growth independent of synaptic activity

    William D Constance et al.
    Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Oncogenesis: Taking the brakes off telomerase

    Kamila Naxerova, Stephen J Elledge
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  1. Point of View: Priority of discovery in the life sciences

    Ronald D Vale, Anthony A Hyman
    Disclosing work prior to submission to a journal would benefit scientists seeking to be acknowledged for their discoveries.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Plant Disease: Autophagy under attack

    Paul de Figueiredo, Marty Dickman
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    1. Cancer Biology

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman et al.
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Point of View: The challenges faced by living stock collections in the USA

    Kevin McCluskey et al.
    Living stock collections provide invaluable resources to research communities, yet they face significant challenges.
  2. Point of View: A fair deal for PhD students and postdocs

    Henry R Bourne
    The relentless expansion that threatens the sustainability of biomedical research in the US takes a heavy toll on young researchers.
    1. Microbiology and Infectious Disease
    2. Ecology

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg
    Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.
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