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459 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

    Francesco Beghini et al.
    The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson et al.
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Aging: The temporary cost of dominance

    Calen P Ryan, Christopher W Kuzawa
    In a population of wild baboons, a new way to assess biological age reveals a surprising effect of social hierarchy.
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    1. Evolutionary Biology
    2. Genetics and Genomics

    The cis-regulatory effects of modern human-specific variants

    Carly V Weiss et al.
    A genome-wide catalog of the regulatory effects of variants that separate modern humans from archaic humans.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.
    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient DNA reveals the lost domestication history of South American camelids in Northern Chile and across the Andes

    Paloma Diaz-Maroto et al.
    aDNA revealed a model of domestication where an ancient guanaco population no longer exists, the loss of the ancient vicuña genetic variation in the modern populations, and frequently interbreeding practices.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

    Michael Roland Wolff et al.
    The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.
    1. Structural Biology and Molecular Biophysics

    Switch-like control of helicase processivity by single-stranded DNA binding protein

    Barbara Stekas et al.
    A single-stranded DNA binding protein stimulates helicase-mediated DNA unwinding by transiently activating a latent processivity switch in the helicase.
    1. Immunology and Inflammation
    2. Medicine

    Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

    Ada Weinstock et al.
    Wnt signaling is revealed to be a regulator of macrophage inflammation-resolving state in atherosclerosis through a PGE2-mediated pathway.
    1. Genetics and Genomics

    Reprogramming of translation in yeast cells impaired for ribosome recycling favors short, efficiently translated mRNAs

    Swati Gaikwad et al.
    A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.

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