Motoneuron activity provides feedback to the spinal network responsible for generating locomotion in the developing mouse spinal cord.

Purinergic keratinocyte-to-sensory neuron signaling is a ubiquitous amplification mechanism that is required for normal mechanical, cold, and heat sensation in vivo.

Avoiding danger requires inhibitory signaling in the prelimbic prefrontal cortex, as evidenced by optogenetic manipulations based on neuronal firing patterns.

Projections from the prelimbic prefrontal cortex targeting the ventral striatum or the basolateral amygdala bidirectionally regulate platform-mediated active avoidance in rats.

Discrete classes of cerebellar Purkinje neurons show distinct changes in synaptic and spiking activity during motor learning, with simple spikes playing a shifting role during acquisition, expression, and maintenance of learned responses.

Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.

During behavior, many neurons do not have classic trial-averaged responses to behaviorally relevant stimuli, but can still have activity and population dynamics related to stimulus and behavioral choice on single trials.

Adult neurogenesis, although happening at a slow rate in the adult brain, plays an important role in learning and memory and has the ability to powerfully modulate large scale neural networks.

A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.

A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.