The coordinated differential modulation of satiety signaling POMC- and hunger signaling AgRP- neurons in the arcuate nucleus of the hypothalamus assigns an important role to noradrenalin to promote feeding.
CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
The Acyl-CoA binding domain-containing 7 (Acbd7) gene is expressed in the hypothalamus, encodes a peptide that suppresses appetite, increases metabolic rate and interacts with the leptin-melanocortin system.
Kisspeptin neurons in the hypothalamus release peptide and amino acid neurotransmitters that work together to coordinate the activity of gonadotropin-releasing hormone neurons and subsequent release of reproductive hormones.
Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of gonadotropin-releasing hormone.
