207 results found
    1. Microbiology and Infectious Disease

    Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

    Kim R Blasdell et al.
    New mammarenaviruses have been identified from rodents in Cambodia and Thailand, and the Cardamones variant of Wēnzhōu virus has been found in Cambodian patients presenting with fever and respiratory symptoms.
    1. Ecology
    2. Microbiology and Infectious Disease

    Endangered wild salmon infected by newly discovered viruses

    Gideon J Mordecai et al.
    Newly discovered viruses in dead and dying farmed Chinook salmon are widely distributed in threatened wild Chinook and sockeye salmon populations.
    1. Chromosomes and Gene Expression

    Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

    Emily Hsu et al.
    CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.
    1. Genetics and Genomics

    Start codon disruption with CRISPR/Cas9 prevents murine Fuchs’ endothelial corneal dystrophy

    Hironori Uehara et al.
    Adenoviral CRISPR/Cas9 gene knockdown of mutant Col8a2 achieves structural and functional rescue of murine Fuchs’ endothelial corneal dystrophy, the first demonstration of post-mitotic CRISPR-based knockdown for phenotypic restoration.
    1. Microbiology and Infectious Disease

    Type I interferon underlies severe disease associated with Junín virus infection in mice

    Brady T Hickerson et al.
    The first lethal Junín virus challenge model in immunocompetent mice provides insight into New World mammarenavirus pathogenesis and will serve as a model for the development of much-needed therapeutic interventions.
    1. Structural Biology and Molecular Biophysics

    Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

    Claire Dickson et al.
    Phosphorylation deactivates TRIM21 B Box autoinhibition to licence proinflammatory signalling by cytosolic antibodies.
    1. Microbiology and Infectious Disease

    Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses

    Ci-Xiu Li et al.
    Extensive genetic diversity and novel genome structures in RNA viruses from arthropods shed important new light on the ancestry and evolutionary history of major classes of vertebrate and plant viruses.
    1. Cell Biology

    Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

    Ana Paula Arruda et al.
    Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

    Ceri A Fielding et al.
    The human cytomegalovirus US12 gene family work co-operatively to degrade large numbers of immune ligands and prevent recognition by natural killer cells.
    1. Developmental Biology

    Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells

    Jonghyeob Lee et al.
    Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.

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