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    1. Biochemistry and Chemical Biology

    JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

    Schuyler Lee, Haolin Liu ... Gongyi Zhang
    JMJD6 helps BRD4 to recruit CDK9 to RNA Polymerase II by disrupting 7SK snRNP complex.
    1. Plant Biology

    Unraveling the role of urea hydrolysis in salt stress response during seed germination and seedling growth in Arabidopsis thaliana

    Yuanyuan Bu, Xingye Dong ... Shenkui Liu
    Salt stress triggers excessive hydrolysis of arginine-derived urea in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, providing new insights into the relationship between seed nitrogen mobilization and seed germination inhibition.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani, Jingwen Song ... Stéphane Richard
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Cancer Biology
    2. Cell Biology

    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

    Maxim I Maron, Alyssa D Casill ... David Shechter
    Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.
    1. Cancer Biology
    2. Cell Biology

    RETRACTED: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu, Lingling Li ... Yu Zhang
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    How lamina-associated polypeptide 1 (LAP1) activates Torsin

    Brian A Sosa, F Esra Demircioglu ... Thomas U Schwartz
    LAP1 adopts an AAA+ like fold that, while unable to bind nucleotide, can enhance ATPase activity in the neighboring TorsinA protomer in an unusual heterohexameric ring, via an arginine finger.
    1. Biochemistry and Chemical Biology

    A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

    Xiao-Chuan Cai, Tuo Zhang ... Minkui Luo
    A chemical probe was characterized for potency, selectivity, and ability to alter CARM1-dependent epigenetic plasticity against cancer cell invasion.
    1. Cell Biology
    2. Neuroscience

    RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response

    Agnieszka Konopacka, Mingkwan Greenwood ... David Murphy
    Caprin-2 is up-regulated in the rat hypothalamus by osmotic stress and controls vital homeostatic osmoregulatory mechanisms by altering the length of the poly(A) tail on arginine vasopressin mRNAs.
    1. Cell Biology
    2. Neuroscience

    Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

    Angela Kim, Jakob G Knudsen ... Linford JB Briant
    A novel process by which counter-regulatory glucagon release is regulated in both mouse and human.
    1. Biochemistry and Chemical Biology

    Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

    Li Zhang, Ngoc-Tung Tran ... Xinyang Zhao
    Inhibiting PRMT1 enzymatic activity promotes megakaryocyte terminal differentiation via RBM15-mediated RNA metabolism, which is dysregulated in hematological malignancies.